Pathways involved in acetaminophen hepatotoxicity with specific targets for inhibition/downregulation

Author:

Karthivashan Govindarajan12345,Arulselvan Palanisamy12345,Fakurazi Sharida12345

Affiliation:

1. Laboratory of Vaccines and Immunotherapeutics

2. Institute of Bioscience

3. Universiti Putra Malaysia

4. Serdang

5. Malaysia

Abstract

Insights on molecular/immunological mechanisms involve in APAP hepatotoxicity and pave way for researchers/clinicians/pharma bodies to identify novel biomarkers, effective bioactive candidates and fruitful therapy against APAP hepatotoxicity.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference82 articles.

1. A. Sendensky and J.-F.Dufour, in Chronic Liver Failure, ed. P. Ginès, P. S. Kamath and V. Arroyo, Humana Press, 2011, pp. 33–45

2. Histological patterns in drug-induced liver disease

3. Drug-Induced Liver Injury

4. J. D. P. Gerald , Acetaminophen: Background and Overview, 2009, available in http://www.fda.gov/SiteIndex/default.htm

5. An Analysis ofN-Acetylcysteine Treatment for Acetaminophen Overdose Using a Systems Model of Drug-Induced Liver Injury

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