Optimal delivery strategies for nanoparticle-mediated mRNA delivery

Author:

Li Xiaoyan12,Guo Xiaocui2,Hu Mingdi23,Cai Rong2ORCID,Chen Chunying234ORCID

Affiliation:

1. Henan Institute of Advanced Technology, Zhengzhou University, Zhengzhou 450001, China

2. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety & CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China

3. University of Chinese Academy of Sciences, Beijing 100049, China

4. The GBA National Institute for Nanotechnology Innovation, Guangzhou 510700, China

Abstract

The nanoparticle-bio interaction occurs at overall stages during thein vivojourney of nanoparticle-mRNA formulations. Optimal delivery strategies based nano-bio interaction is dedicated for an ideal mRNA delivery system.

Funder

National Natural Science Foundation of China

China Postdoctoral Science Foundation

National Key Research and Development Program of China

Chinese Academy of Medical Sciences

Chinese Academy of Sciences

Beijing Nova Program

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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