Stereoisomers of octahydrocurcumin, the hydrogenated metabolites of curcumin, display stereoselective activity on the CYP2E1 enzyme in L-02 cells-Reference-Cited by-同舟云学术

Stereoisomers of octahydrocurcumin, the hydrogenated metabolites of curcumin, display stereoselective activity on the CYP2E1 enzyme in L-02 cells

Published:2023 Issue:6 Volume:14 Page:2822-2835
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Luo Dandan¹,Lin Yinsi²^ORCID,Chen Jiannan²^ORCID,Huang Xiaoqi²,Xie Youliang²,Liu Yuhong²,Ni Suiqin¹,Su Ziren²^ORCID,Li Yucui²,Zhang Zhenbiao³^ORCID

Affiliation:

1. Department of clinical pharmacy, Guangzhou First People's Hospital, South China University of Technology, Guangzhou 510180, P.R. China

2. School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, P.R. China

3. Tea Research Institute, Guangdong Academy of Agricultural Sciences, Guangdong Key Laboratory of Tea Resources Innovation & Utilization, Guangzhou 510640, China

Abstract

Stereoisomers of octahydrocurcumin, the hydrogenated metabolites of curcumin, display stereo-selective activity on the CYP2E1 enzyme in L-02 cells, which finally induces more effective liver protection effects in acetaminophen-induced L-02 injury.

Funder

Guangzhou Municipal Science and Technology Project

Basic and Applied Basic Research Foundation of Guangdong Province

Guangdong Academy of Agricultural Sciences

Natural Science Foundation of Guangdong Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/FO/D2FO03892G