Dithiocarbamate-based novel anti-histaminic agents: synthesis, characterization, crystal structure and thermal study

Author:

Singh Anupam1ORCID,Kumar Rajesh23,Patel Riya1ORCID,Trishna 1ORCID,Gautam Ram Nayan1ORCID,Bharty M. K.1ORCID,Prasad Lal Bahadur1ORCID

Affiliation:

1. Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, India

2. Department of Pharmacology, Institute of Medical Science, Banaras Hindu University, Varanasi - 221005, India

3. Department of Pharmacology, Maharaja Agrasen School of Pharmacy, Maharaja Agrasen University, Solan, Himachal Pradesh – 174103, India

Abstract

Complexes of Co(iii) (1), Ni(ii) (2), Cu(ii) (3), and Zn(ii) (4) derived from an N-(4-fluorobenzyl) N-(pyridin-2-ylmethyl) dithiocarbamate ligand. Complex 3 showed maximum reduction in clonidine-induced catalepsy after 180 minutes of treatment.

Funder

Banaras Hindu University

University Grants Commission

Publisher

Royal Society of Chemistry (RSC)

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