<i>In vivo</i> stability of <sup>211</sup>At-radiopharmaceuticals: on the impact of halogen bond formation-Reference-Cited by-同舟云学术

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In vivo stability of ²¹¹At-radiopharmaceuticals: on the impact of halogen bond formation

Published:2024 Issue:1 Volume:15 Page:223-233
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Yssartier Thibault¹²,Liu Lu³,Pardoue Sylvain²,Le Questel Jean-Yves¹,Guérard François⁴^ORCID,Montavon Gilles²,Galland Nicolas¹^ORCID

Affiliation:

1. CNRS, CEISAM UMR 6230, Nantes Université, F-44000 Nantes, France

2. CNRS, SUBATECH UMR 6457, IMT Atlantique, F-44307 Nantes, France

3. CNRS, IPHC UMR 7178, Université de Strasbourg, F-67037 Strasbourg, France

4. Inserm UMR 1307, CNRS UMR 6075, CRCI2NA, Nantes Université, Université d'Angers, F-44000 Nantes, France

Abstract

Astatine's ability to form halogen bond interactions with iodothyronine deiodinases regulates the in vivo stability of astatoaryl prosthetic groups.

Funder

European Research Council

Agence Nationale de la Recherche

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D3MD00579H

Reference67 articles.

1. Overview of the Most Promising Radionuclides for Targeted Alpha Therapy: The “Hopeful Eight”

2. Clinical Experience with α-Particle–Emitting 211At: Treatment of Recurrent Brain Tumor Patients with 211At-Labeled Chimeric Antitenascin Monoclonal Antibody 81C6

3. Intraperitoneal α-Particle Radioimmunotherapy of Ovarian Cancer Patients: Pharmacokinetics and Dosimetry of 211At-MX35 F(ab′)2—A Phase I Study

4. Advances in the Chemistry of Astatine and Implications for the Development of Radiopharmaceuticals

5. Labeling monoclonal antibodies and F(ab')2 fragments with the alpha-particle-emitting nuclide astatine-211: preservation of immunoreactivity and in vivo localizing capacity.

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