An intracellular protein delivery platform based on glutathione-responsive protein nanocapsules-Reference-Cited by-同舟云学术

An intracellular protein delivery platform based on glutathione-responsive protein nanocapsules

Published:2016 Issue:93 Volume:52 Page:13608-13611
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Li Jie¹²³⁴,Zhang Linlin⁵⁶⁷⁸⁹,Liu Yang¹²³⁴¹⁰,Wen Jing¹¹¹²³⁴,Wu Di¹²³⁴,Xu Duo¹²³⁴,Segura Tatiana¹²³⁴,Jin Jing¹³¹⁴⁹,Lu Yunfeng¹²³⁴,Wang Hui⁵⁶⁷⁸⁹

Affiliation:

1. Department of Chemical and Biomolecular Engineering

2. University of California, Los Angeles

3. Los Angeles

4. USA

5. Department of Nuclear Medicine

6. Xinhua Hospital Affiliated to Shanghai Jiao Tong University

7. Shanghai Jiao Tong University

8. Shanghai 200092

9. China

10. Key Laboratory of Functional Polymer Materials of Ministry of Education and State Key Laboratory of Medicinal Chemical Biology

11. Department of Microbiology, Immunology, and Molecular Genetics

12. University of California

13. Diagnosis Biotech Co., Ltd

14. Nanjing

Abstract

We reported an efficient strategy for the intracellular delivery of proteins based on assembling proteins with a self-crosslinkable polymer. The disulfide-crosslinking structure enhances the stability of the protein–polymer assembly, and also allows effective dissociation of the assembly in response to glutathione.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2016/CC/C6CC05099A

Reference24 articles.

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