A bivalent inhibitor against TDRD3 to suppress phase separation of methylated G3BP1-Reference-Cited by-同舟云学术

A bivalent inhibitor against TDRD3 to suppress phase separation of methylated G3BP1

Published:2024 Issue:6 Volume:60 Page:762-765
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Fan Wei-Wei¹,Xu Tian¹,Gao Jia¹,Zhang Han-Yu¹,Li Yan²,Hu Duo-Duo²,Gao Shuaixin³,Zhang Jia-Hai¹,Liu Xing¹,Liu Dan¹,Li Pi-Long⁴,Wong Catherine C. L.³,Yao Xue-Biao¹,Shi Yun-Yu¹,Yang Zhen-Ye¹,Wang Xi-Sheng²^ORCID,Ruan Ke¹^ORCID

Affiliation:

1. The First Affiliated Hospital & School of Life Sciences, Ministry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, Hefei National Research Center for Interdisciplinary Sciences at the Microscale, Biomedical Sciences and Health Laboratory of Anhui Province, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China

2. Department of Chemistry, University of Science and Technology of China, Hefei 230026, China

3. Center for Precision Medicine Multi-omics Research, Peking University Health Science Center, Peking University First Hospital; School of Basic Medical Sciences, Peking University Health Science Center; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China

4. Beijing Advanced Innovation Center for Structural Biology & Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084, China

Abstract

A bivalent inhibitor was uncovered to block the multivalent interactions among stress granules.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Natural Science Foundation of Anhui Province

University of Science and Technology of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CC/D3CC04654K

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1. A framework for understanding the functions of biomolecular condensates across scales

2. What lava lamps and vinaigrette can teach us about cell biology

3. Transcription regulation enters a new phase

4. Beating the heat: Phase separation in plant stress granules

5. Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology