An organometallic analogue of combretastatin A-4 and its apoptosis-inducing effects on lymphoma, leukemia and other tumor cells <i>in vitro</i>-Reference-Cited by-同舟云学术

An organometallic analogue of combretastatin A-4 and its apoptosis-inducing effects on lymphoma, leukemia and other tumor cells in vitro

Published:2022 Issue:9 Volume:13 Page:1044-1051
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Abodo Onambele Liliane¹²,Hoffmann Natalie³,Kater Lisa²,Hemmersbach Lars³,Neudörfl Jörg-Martin³,Sitnikov Nikolay³,Kater Benjamin²,Frias Corazon²⁴⁵,Schmalz Hans-Günther³^ORCID,Prokop Aram¹²⁴⁵

Affiliation:

1. Department of Pediatric Oncology/Hematology, Children's Hospital of the City of Cologne, Amsterdamer Str. 59, 50735 Cologne, Germany

2. Department of Pediatric Oncology/Hematology, University Medical Center Charité, Campus Virchow, Augustenburger Pl. 1, 13353 Berlin, Germany

3. Department of Chemistry, University of Cologne, Greinstrasse 4, 50939 Cologne, Germany

4. Department of Pediatric Hematology/Oncology, Helios Clinic Schwerin, 19055 Schwerin, Germany

5. MSH Medical School Hamburg, Am Kaiserkai 1, 20457 Hamburg, Germany

Abstract

The diarylethyne cobalt carbonyl complex NAHO27 selectively induces apoptosis in cancer cells at low μM concentrations via the mitochondrial pathway. It is also active against resistant cells, showing a strong synergistic effect with vincristine.

Funder

Deutsche Forschungsgemeinschaft

Alexander von Humboldt-Stiftung

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/MD/D2MD00144F

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