Combinatorial photochemotherapy on liver cancer stem cells with organoplatinum(ii) metallacage-based nanoparticles

Author:

Yang Beng12345,Liu Hua12345,Yang Huang67589,Chen Wei1011129,Wu Jingban12345,Feng Xiaode12345,Tong Rongliang12345,Yu Hanxi12345,Chen Yunhao12345,Lv Zhen12345,Sun Weijian2134149,He Bin12345,Wu Jian12345,Yu Guocan1516171819,Mao Zhengwei67589ORCID,Zheng Shusen12345

Affiliation:

1. Division of Hepatobiliary and Pancreatic Surgery

2. Department of Surgery

3. First Affiliated Hospital

4. School of Medicine

5. Zhejiang University

6. MOE Key Laboratory of Macromolecular Synthesis and Functionalization

7. Department of Polymer Science and Engineering

8. Hangzhou 310027

9. China

10. Department of General Medicine

11. Second Affiliated Hospital of Zhejiang Chinese Medical University

12. Hangzhou

13. The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University

14. Wenzhou 325027

15. Laboratory of Molecular Imaging and Nanomedicine

16. National Institute of Biomedical Imaging and Bioengineering

17. National Institutes of Health

18. Bethesda

19. USA

Abstract

Metallacage-based nanoparticles have superior therapeutic performance against liver cancer stem cells in both traditional 2D model and 3D multicellular spheroids, providing a promising strategy for efficient cancer treatment.

Funder

National Natural Science Foundation of China

National Health and Family Planning Commission of the People's Republic of China

Science and Technology Department of Zhejiang Province

Natural Science Foundation of Zhejiang Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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