Dietary gluten worsens hepatic steatosis by increasing inflammation and oxidative stress in ApoE−/− mice fed a high-fat diet-Reference-Cited by-同舟云学术

Dietary gluten worsens hepatic steatosis by increasing inflammation and oxidative stress in ApoE−/− mice fed a high-fat diet

Published:2023 Issue:7 Volume:14 Page:3332-3347
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Aguilar Edenil Costa¹^ORCID,Fernandes-Braga Weslley¹²^ORCID,Leocádio Paola Caroline Lacerda¹,Campos Gianne Paul³,Lemos Virginia Soares⁴,de Oliveira Rafael Pires⁵,Caetano de Faria Ana Maria¹,dos Santos Aggum Capettini Luciano³,Alvarez-Leite Jacqueline I.¹^ORCID

Affiliation:

1. Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais/UFMG, Caixa Postal 486, 30161-970 Belo Horizonte, Brazil

2. Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York, USA

3. Department of Pharmacology, Federal University of Minas Gerais, Belo Horizonte, Brazil

4. Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, Brazil

5. Colégio Militar de Curitiba, Paraná, Brazil

Abstract

Gluten exacerbated hepatic lipid deposition and damage, inducing increased expression of NF-κB and AP1, which culminated in increased inflammation and oxidative stress. Gluten increased: blood neutrophils, and NK cells and Treg cells in the spleen.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação de Amparo à Pesquisa do Estado de Minas Gerais

Pró-Reitoria de Pesquisa, Universidade Federal de Minas Gerais

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/FO/D3FO00149K

Reference102 articles.