Photocrosslinkable, biodegradable hydrogels with controlled cell adhesivity for prolonged siRNA delivery to hMSCs to enhance their osteogenic differentiation-Reference-Cited by-同舟云学术

Photocrosslinkable, biodegradable hydrogels with controlled cell adhesivity for prolonged siRNA delivery to hMSCs to enhance their osteogenic differentiation

Published:2017 Issue:3 Volume:5 Page:485-495
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Nguyen Minh Khanh¹²³⁴,McMillan Alexandra⁵²³⁴,Huynh Cong Truc¹²³⁴^ORCID,Schapira Daniel S.¹²³⁴,Alsberg Eben¹²³⁴⁶

Affiliation:

1. Department of Biomedical Engineering

2. Case Western Reserve University

3. Cleveland

4. USA

5. Department of Pathology

6. Department of Orthopaedic Surgery

Abstract

Sustained and localized delivery of siRNA from photocrosslinked dextran hydrogels can enhance human mesenchymal stem cell osteogenesis.

Funder

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2017/TB/C6TB01739H

Reference83 articles.

1. Polymer-based siRNA delivery: Perspectives on the fundamental and phenomenological distinctions from polymer-based DNA delivery

2. RNA interference therapy via functionalized scaffolds

3. Localized, Targeted, and Sustained siRNA Delivery

4. Before and after Endosomal Escape: Roles of Stimuli-Converting siRNA/Polymer Interactions in Determining Gene Silencing Efficiency

5. siRNA Versus miRNA as Therapeutics for Gene Silencing

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