Real-time cell metabolism assessed repeatedly on the same cells <i>via</i> para-hydrogen induced polarization-Reference-Cited by-同舟云学术

Real-time cell metabolism assessed repeatedly on the same cells via para-hydrogen induced polarization

Published:2023 Issue:28 Volume:14 Page:7642-7647
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Ding Yonghong¹²,Stevanato Gabriele¹²^ORCID,von Bonin Frederike³,Kube Dieter³,Glöggler Stefan¹²^ORCID

Affiliation:

1. Group of NMR Signal Enhancement Max Planck Institute for Multidisciplinary Sciences, Am Fassberg 11, 37077 Göttingen, Germany

2. Center for Biostructural Imaging of Neurodegeneration University Medical Center Göttingen, Von-Siebold-Str. 3A, 37075 Göttingen, Germany

3. Clinic for Hematology and Medical Oncology University Medical Center Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany

Abstract

We propose a fast protocol that enables two parahydrogen induced polarization measurements on the same cell sample and yield kinetic rates of metabolic conversion under inhibition and stimulation conditions.

Funder

Deutsche Forschungsgemeinschaft

Horizon 2020 Framework Programme

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC01350B

Reference57 articles.

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