Evolutionary adaptation from hydrolytic to oxygenolytic catalysis at the α/β-hydrolase fold

Author:

Bui Soi1ORCID,Gil-Guerrero Sara2ORCID,van der Linden Peter3ORCID,Carpentier Philippe45ORCID,Ceccarelli Matteo67ORCID,Jambrina Pablo G.2ORCID,Steiner Roberto A.18ORCID

Affiliation:

1. Randall Centre for Cell and Molecular Biophysics, King's College London, London SE1 1UL, UK

2. Departamento de Química Física, University of Salamanca, Salamanca 37008, Spain

3. European Synchrotron Radiation Facility (ESRF), Partnership for Soft Condensed Matter (PSCM), 71 Avenue des Martyrs, Grenoble 38000, France

4. European Synchrotron Radiation Facility (ESRF), 71 Avenue des Martyrs, 38043 Grenoble, France

5. Université Grenoble Alpes, CNRS, CEA, Interdisciplinary Research Institute of Grenoble (IRIG), Laboratoire Chimie et Biologie des Métaux (LCBM) UMR 5249, 17 Avenue des Martyrs, 38054 Grenoble, France

6. Department of Physics, University of Cagliari, Monserrato 09042, Italy

7. IOM-CNR Unità di Cagliari, Cittadella Universitaria, Monserrato 09042, Italy

8. Department of Biomedical Sciences, University of Padova, Italy

Abstract

We report how the common α/β-hydrolase architecture and its simple catalytic machinery have been adapted to accomplish spin-restricted metal-independent oxygenation.

Funder

Ministerio de Ciencia e Innovación

Biotechnology and Biological Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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