Prevention of esophageal stenosis via in situ cross-linkable alginate/gelatin powder in a new submucosal exfoliation model in rats

Author:

Pan Qi1,Tsuji Yosuke2ORCID,Sreedevi Madhavikutty Athira3ORCID,Ohta Seiichi145ORCID,Fujisawa Ayano5,Inagaki Natsuko F.1ORCID,Fujishiro Mitsuhiro2,Ito Taichi135ORCID

Affiliation:

1. Center for Disease Biology and Integrative Medicine, School of Medicine, the University of Tokyo, Japan

2. Department of Gastroenterology, School of Medicine, the University of Tokyo, Japan

3. Department of Chemical System Engineering, School of Engineering, the University of Tokyo, Japan

4. Institute of Engineering Innovation, School of Engineering, the University of Tokyo, Japan

5. Department of Bioengineering, School of Engineering, the University of Tokyo, Japan

Abstract

An in situ cross-linkable powder composed of alginate, gelatin, transglutaminase (TG), and calcium chloride ions (Ca2+) could prevent esophageal stenosis after endoscopic submucosal dissection (ESD) using novel rat ESD model.

Funder

Japan Agency for Medical Research and Development

Mochida Pharmaceutical Company

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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