Hierarchical integration of degradable mesoporous silica nanoreservoirs and supramolecular dendrimer complex as a general-purpose tumor-targeted biomimetic nanoplatform for gene/small-molecule anticancer drug co-delivery

Author:

Fei Yang1234,Li Menghuan1234,Li Yanan1234,Wang Xuan1234,Xue Chencheng56234,Wu Zuosu7894,Xu Jiaying1011124,Xiazeng Zilu56234ORCID,Cai Kai-Yong56234ORCID,Luo Zhong1234ORCID

Affiliation:

1. School of Life Science

2. Chongqing University

3. Chongqing 400044

4. P. R. China

5. Key Laboratory of Biorheological Science and Technology

6. Ministry of Education

7. School & Hospital of stomatology

8. Wenzhou Medical University

9. Wenzhou

10. School of Biology & Basic Medical Science

11. Soochow University

12. Suzhou

Abstract

A biomimetic nanosystem was developed through the hierarchical integration of degradable dendritic mesoporous silica nanoparticles and functional dendrimers for the tumor-targeted delivery of genes and small-molecule anticancer drugs.

Funder

National Natural Science Foundation of China

National Basic Research Program of China

Natural Science Foundation of Chongqing

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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