Critical aspects in dissolution testing of nanomaterials in the oro-gastrointestinal tract: the relevance of juice composition for hazard identification and grouping

Author:

Di Cristo Luisana1,Keller Johannes G.2,Leoncino Luca3ORCID,Marassi Valentina4,Loosli Frederic25,Seleci Didem Ag2,Tsiliki Georgia6,Oomen Agnes G.78,Stone Vicki9,Wohlleben Wendel2ORCID,Sabella Stefania1ORCID

Affiliation:

1. Istituto Italiano Di Tecnologia, Nanoregulatory Group, D3PharmaChemistry, Genova, Italy

2. Department of Material Physics and Department of Experimental Toxicology and Ecology, BASF SE, Ludwigshafen, Germany

3. Electron Microscopy Facility, Istituto Italiano di Tecnologia, Genova, Italy

4. Department of Chemistry “G. Ciamician”, University of Bologna, Italy

5. University of Vienna, Vienna, Austria

6. Institute for the Management of Information Systems, Athena Research Center, Marousi, Greece

7. National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands

8. University of Amsterdam, Amsterdam, The Netherlands

9. Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University, Edinburgh, UK

Abstract

Rational design of analytical criteria to perform dissolution testing of nanomaterials: the relevance of juice composition for hazard identification and grouping.

Funder

European Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Materials Science,General Chemistry,Atomic and Molecular Physics, and Optics,Bioengineering

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