SARS-CoV-2 virus-like-particles via liposomal reconstitution of spike glycoproteins

Author:

McColman Sarah12ORCID,Shkalla Klaidi12ORCID,Sidhu Pavleen12,Liang Jady23ORCID,Osman Selena12,Kovacs Norbert12,Bokhari Zainab12,Forjaz Marques Ana Carolina124,Li Yuchong235,Lin Qiwen235,Zhang Haibo2356ORCID,Cramb David T.127ORCID

Affiliation:

1. Department of Chemistry and Biology, Faculty of Science, Toronto Metropolitan University, Toronto, ON, Canada

2. Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Unity Health Toronto, Toronto, ON, Canada

3. Department of Physiology, University of Toronto, Toronto, ON, Canada

4. Faculdade de Ciências Farmacêuticas, Seção Técnica de Graduação, Universidade Estadual Paulista, Araraquara, SP, Brazil

5. The State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China

6. Departments of Anaesthesia and Physiology, Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada

7. Department of Chemistry, Faculty of Science, University of Calgary, Calgary, AB, Canada

Abstract

SARS-CoV-2 spike glycoproteins reconstituted into liposome-based virus-like particles show binding to ACE-2 receptors and are internalized by lung epithelial cells.

Funder

Canadian Institutes of Health Research

Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada

University of Calgary

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Materials Science,General Chemistry,Atomic and Molecular Physics, and Optics,Bioengineering

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Bio-inspired hierarchical particles for bioassays;Biomedical Technology;2024-06

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