Wound microenvironment regulatory poly(l-glutamic acid) composite hydrogels containing metal ion-coordinated nanoparticles for effective hemostasis and wound healing

Author:

Chen Yanzheng1,Zhang Xueliang1,Wang Qing2,Du Chang34,Dong Chang-Ming1ORCID

Affiliation:

1. School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China

2. Department of Stomatology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, 200080, P. R. China

3. Clinical Cancer Institute, Center for Translational Medicine, Naval Military Medical University, Shanghai, 200433, P. R. China

4. State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China

Abstract

A wound microenvironment regulatory poly(l-glutamic acid) composite hydrogel can promote cell proliferation, migration, and angiogenesis, alleviate inflammation and polarize pro-inflammatory M1 macrophages into pro-healing M2 macrophages, thus accelerating wound healing.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Shanghai

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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