A metal π-Lewis base activation model for Pd-catalyzed hydroamination of amines and 1,3-dienes-Reference-Cited by-同舟云学术

A metal π-Lewis base activation model for Pd-catalyzed hydroamination of amines and 1,3-dienes

Published:2023 Issue:17 Volume:14 Page:4597-4604
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Yan Xiao¹,Yang Xiu-Ming¹,Yan Peng¹,Zhao Bo¹,Zeng Rong¹,Pan Bin¹,Chen Ying-Chun¹²^ORCID,Zhu Lei¹^ORCID,Ouyang Qin¹^ORCID

Affiliation:

1. College of Pharmacy, Third Military Medical University, Shapingba, Chongqing 400038, China

2. Key Laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education, Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China

Abstract

We propose a metal π-Lewis base activation model for Pd-catalyzed hydroamination of amines and 1,3-dienes, wherein the electron-rich Pd(0) was considered as a Lewis base to activate dienesviaπ-back donation.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D2SC05835A

Reference62 articles.

1. Hydroamination: Direct Addition of Amines to Alkenes and Alkynes

2. Late Transition Metal-Catalyzed Hydroamination and Hydroamidation

3. Palladium(0)-Catalyzed Difunctionalization of 1,3-Dienes: From Racemic to Enantioselective

4. Asymmetric synthesis of allylic compounds via hydrofunctionalisation and difunctionalisation of dienes, allenes, and alkynes

5. Hydroamination of non-activated alkenes with ammonia: a holy grail in catalysis

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