From the journal:

Natural Product Reports

Recent advances in the total synthesis of galantamine, a natural medicine for Alzheimer's disease

Bichu Cheng, ORCID logo ac   Qi Wang,c   Yi An ORCID logo a  and  Fener Chen ORCID logo *abc  

* Corresponding authors

a Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China
E-mail: rfchen@fudan.edu.cn

b College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang, Jiangxi 330022, China

c School of Science, Green Pharmaceutical Engineering Research Center, Harbin Institute of Technology, Shenzhen 518055, China

Abstract

Covering: 2006 to 2023

(−)-Galantamine is a natural product with distinctive structural features and potent inhibitory activity against acetylcholine esterase (AChE). It is clinically approved for the treatment of Alzheimer's disease. The clinical significance and scarcity of this natural product have prompted extensive and ongoing efforts towards the chemical synthesis of this challenging tetracyclic structure. The objective of this review is to summarize and discuss recent progress in the total synthesis of galantamine from 2006 to 2023. The contents are organized according to the synthetic strategies for the construction of the quaternary center. Key features of each synthesis have been highlighted, followed by a summary and outlook at the end.

Graphical abstract: Recent advances in the total synthesis of galantamine, a natural medicine for Alzheimer's disease

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Article information

DOI
https://doi.org/10.1039/D4NP00001C
Article type
Review Article
Submitted
05 Jan 2024
First published
07 Mar 2024
This article is Open Access
Creative Commons BY-NC license

Nat. Prod. Rep., 2024, Advance Article

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Recent advances in the total synthesis of galantamine, a natural medicine for Alzheimer's disease

B. Cheng, Q. Wang, Y. An and F. Chen, Nat. Prod. Rep., 2024, Advance Article , DOI: 10.1039/D4NP00001C

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