A ratiometric fluorescent probe revealing the abnormality of acetylated tau by visualizing polarity in Alzheimer's disease-Reference-Cited by-同舟云学术

A ratiometric fluorescent probe revealing the abnormality of acetylated tau by visualizing polarity in Alzheimer's disease

Published:2024 Issue:23 Volume:12 Page:5619-5627
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Sun Panpan¹²,Chen Hai-Chao³,Guo Wenting¹^ORCID,Zhang Zefan¹,Sun Shihao¹,Gao Ningshuang¹,Jing Yu-Hong³,Wang Baodui¹^ORCID

Affiliation:

1. State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Lanzhou University, Lanzhou, Gansu 730000, People's Republic of China

2. College of Chemistry & Chemical Engineering, Northwest Normal University, Lanzhou 730070, People's Republic of China

3. Institute of Anatomy and Histology & Embryology, Neuroscience, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, People's Republic of China

Abstract

A ratiometric fluorescent probe with high fluorescence efficiency in hydrophilic environment was developed. The probe not only tracked changes in cell polarity, but also found abnormal brain polarity in APP/PS1 mice compared to wild-type mice.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Science and Technology Department of Gansu Province

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/TB/D4TB00357H

Reference55 articles.

1. Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

2. Alzheimer's disease

3. Alzheimer's disease: the benefits of early treatment

4. The Role of Synaptic Proteins in Alzheimer's Disease

5. HDAC6 and RhoA are novel players in Abeta-driven disruption of neuronal polarity