First total synthesis of caerulomycin K: a case study on selective, multiple C–H functionalizations of pyridines-Reference-Cited by-同舟云学术

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First total synthesis of caerulomycin K: a case study on selective, multiple C–H functionalizations of pyridines

Published:2024 Issue:8 Volume:14 Page:5542-5546
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Dimasi Alessandro¹^ORCID,Failla Mattia¹^ORCID,Montoli Arianna¹^ORCID,Citarella Andrea¹^ORCID,Ronchi Paolo²^ORCID,Passarella Daniele¹^ORCID,Fasano Valerio¹^ORCID

Affiliation:

1. Department of Chemistry, Università degli Studi di Milano, Via Camillo Golgi, 19, 20133 Milano, Italy

2. Medicinal Chemistry and Drug Design Technologies Department, Global Research and Preclinical Development, Chiesi Farmaceutici S.p.A, Largo Francesco Belloli 11/a, 43126 Parma, Italy

Abstract

A radical change: the first 3-steps total synthesis of caerulomycin K was achieved exploiting Minisci chemistry using cheap starting materials.

Funder

Chiesi Farmaceutici

Università degli Studi di Milano

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA00589A

Reference47 articles.

1. Pyridine: the scaffolds with significant clinical diversity

2. The Expanding Role of Pyridine and Dihydropyridine Scaffolds in Drug Design

3. C–H functionalization of pyridines

4. Late‐Stage Functionalisation of Pyridine‐Containing Bioactive Molecules: Recent Strategies and Perspectives

5. Late-Stage C–H Functionalization of Azines

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