Potential of hyphenated ultra-high performance liquid chromatography-scheduled multiple reaction monitoring algorithm for large-scale quantitative analysis of traditional Chinese medicines

Author:

Song Qingqing12345,Song Yuelin1234,Zhang Na12345,Li Jun1234,Jiang Yong67894,Zhang Kerong1011124,Zhang Qian1234,Tu Pengfei1234

Affiliation:

1. Modern Research Center for Traditional Chinese Medicine

2. Beijing University of Chinese Medicine

3. Beijing 100029

4. China

5. School of Chinese Materia Medica

6. State Key Laboratory of Natural and Biomimetic Drugs

7. School of Pharmaceutical Sciences

8. Peking University

9. Beijing 100191

10. Application Support Center

11. AB SCIEX

12. Shanghai 200233

Abstract

The combination of a core–shell ADME column with a sMRM algorithm offers the potential for large-scale quantitative analysis of the components in TCMs by providing not only high quality quantitative signals but also reliable MS2 spectra.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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