Citrus flavanone metabolites protect pancreatic-β cells under oxidative stress induced by cholesterol

Author:

Anacleto Sara L.12345ORCID,Milenkovic Dragan678910ORCID,Kroon Paul A.11121314ORCID,Needs Paul W.11121314,Lajolo Franco Maria12345,Hassimotto Neuza M. A.12345ORCID

Affiliation:

1. Food Research Center-(FoRC-CEPID) and Department of Food Science and Nutrition

2. School of Pharmaceutical Science

3. University of São Paulo

4. 05508-900 São Paulo

5. Brazil

6. Department of Internal Medicine

7. Division of Cardiovascular Medicine

8. University of California

9. Davis

10. USA

11. Quadram Institute Bioscience

12. Norwich Research Park

13. Norwich

14. UK

Abstract

Flavanone metabolites decreased the oxidative biomarkers and this effect might be associated with the anti-apoptotic and antioxidant properties of these compounds as well their ability to prevent mitochondrial and insulin secretion dysfunction.

Funder

Fundação de Amparo à Pesquisa do Estado de São Paulo

Biotechnology and Biological Sciences Research Council

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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