An anti-inflammatory chondroitin sulfate-poly(lactic-co-glycolic acid) composite electrospinning membrane for postoperative abdominal adhesion prevention

Author:

Gao Rui1,Li Fenghui2,Zhang Yushan1,Kong Pengxu34,Gao Yu1,Wang Jingrong1,Liu Xiang1,Li Shuangyang1,Jiang Liqin1,Zhang Ju1,Zhang Chuangnian14ORCID,Feng Zujian1,Huang Pingsheng14ORCID,Wang Weiwei14ORCID

Affiliation:

1. Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China

2. Department of Gastroenterology and Hepatology, The Third Central Hospital of Tianjin, Tianjin Key Laboratory of Extra-corporeal Life Support for Critical Diseases, Artificial Cell Engineering Technology Research Center, Tianjin Institute of Hepatobiliary Disease, Tianjin 300170, China

3. Structural Heart Disease Center, National Center for Cardiovascular Disease, China and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China

4. Key Laboratory of Innovative Cardiovascular Devices, Chinese Academy of Medical Sciences, Beijing 100037, China

Abstract

A promising drug-/cytokine-free anti-inflammatory PLGA/CS electrospinning membrane barrier was developed for post-surgery abdominal adhesion prevention by alleviating the local inflammatory response and activating the fibrinolytic system.

Funder

Fundamental Research Funds for the Central Universities

Natural Science Foundation of Tianjin City

Science Fund for Distinguished Young Scholars of Tianjin

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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