Spiroalanpyrroids A and B, sesquiterpene alkaloids with a unique spiro-eudesmanolide–pyrrolizidine skeleton from Inula helenium

Author:

Cai You-Sheng12345ORCID,Wu Zi12345,Zheng Xiao-Qin12345,Wang Cong67895,Wang Jian-Rong101112135,Zhang Xin-Xin12345,Qiu Guofu12345,Zhu Kongkai1415165,Cao Shugeng1718192021,Yu Jianqing12345ORCID

Affiliation:

1. Institute of TCM and Natural Products

2. School of Pharmaceutical Sciences

3. Wuhan University

4. Wuhan 430071

5. People's Republic of China

6. Guangxi Key Laboratory of Chemistry and Engineering of Forest Products

7. School of Chemistry and Chemical Engineering

8. Guangxi University for Nationalities

9. Nanning 530006

10. Pharmaceutical Analytical & Solid-State Chemistry Research Center

11. Shanghai Institute of Materia Medica

12. Chinese Academy of Sciences

13. Shanghai 201203

14. School of Biological Science and Technology

15. University of Jinan

16. Jinan 250022

17. Department of Pharmaceutical Sciences

18. Daniel K. Inouye College of Pharmacy

19. University of Hawai'i at Hilo

20. Hilo 96720

21. USA

Abstract

Two sesquiterpene alkaloids with an unprecedented eudesmanolide–pyrrolizidine spiro[5.5] framework, together with two new sesquiterpene-amino acid adducts were isolated from the roots of Inula helenium.

Funder

National Natural Science Foundation of China

National Basic Research Program of China

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Reference32 articles.

1. National Commission of Chinese Pharmacopoeia of Peoples Republic of China , Chemical Industry Press , Beijing , 2005 , p. 13

2. Sesquiterpenoids, alantolactone analogues, and seco-guaiene from the roots of Inula helenium

3. Editorial Committee of the Administration Bureau of Chinese Plant Medicine , Chinese Flora , Science Press , Beijing , 1979 , pp. 75 , 249

4. The genus Inula and their metabolites: From ethnopharmacological to medicinal uses

5. Total sesquiterpene lactones isolated from Inula helenium L . attenuates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in mice

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