MicroRNA-29b inhibits supernatants from silica-treated macrophages from inducing extracellular matrix synthesis in lung fibroblasts-Reference-Cited by-同舟云学术

MicroRNA-29b inhibits supernatants from silica-treated macrophages from inducing extracellular matrix synthesis in lung fibroblasts

Published:2017 Issue:6 Volume:6 Page:878-888
ISSN:2045-452X
Container-title:Toxicology Research
language:en
Short-container-title:Toxicol. Res.

Author:

Lian Ximeng¹²³⁴⁵,Chen Xiaowei¹²³⁴⁵,Sun Jingping¹²³⁴⁵,An Guoliang¹²³⁴⁵,Li Xiaoli¹²³⁴⁵,Wang Yan¹²³⁴⁵,Niu Piye¹²³⁴⁵^ORCID,Zhu Zhonghui¹²³⁴⁵,Tian Lin¹²³⁴⁵^ORCID

Affiliation:

1. School of Public Health

2. Capital Medical University

3. Beijing 100069

4. China

5. Beijing Key Laboratory of Environmental Toxicology

Abstract

Supernatants from silica-treated macrophages induced the lung fibroblasts proliferation, miR-29b reduced and extracellular matrix synthesis increased, which could be markedly inhibited by overexpression of miR-29b.

Funder

National Natural Science Foundation of China

Publisher

Oxford University Press (OUP)

Subject

Health, Toxicology and Mutagenesis,Toxicology

Link

http://pubs.rsc.org/en/content/articlepdf/2017/TX/C7TX00126F

Reference38 articles.

1. Mechanisms in the Pathogenesis of Asbestosis and Silicosis

2. Bone morphogenetic protein-7 inhibits silica-induced pulmonary fibrosis in rats

3. Role of human pulmonary fibroblast-derived MCP-1 in cell activation and migration in experimental silicosis

4. Macrophages: Master Regulators of Inflammation and Fibrosis

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