Bioactive phytoconstituents as potent inhibitors of casein kinase-2: dual implications in cancer and COVID-19 therapeutics

Author:

Anjum Farah1,Sulaimani Md Nayab2,Shafie Alaa1,Mohammad Taj2,Ashraf Ghulam Md.34ORCID,Bilgrami Anwar L.5,Alhumaydhi Fahad A.6ORCID,Alsagaby Suliman A.7,Yadav Dharmendra Kumar8,Hassan Md. Imtaiyaz2ORCID

Affiliation:

1. Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P. O. Box 11099, Taif 21944, Saudi Arabia

2. Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India

3. Pre-Clinical Research Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia 21589

4. Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia

5. Deanship of Scientific Research, King Abdulaziz University, Jeddah, Saudi Arabia

6. Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi Arabia

7. Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Majmaah 11932, Saudi Arabia

8. College of Pharmacy, Gachon University of Medicine and Science, Hambakmoeiro, Yeonsu-gu, Incheon City 21924, Korea

Abstract

Showing protein–ligands interactions, electrostatic potential of CK2 bound to selected compounds, free energy landscapes of CK2-stylopine, and CK2-dehydroevodiamines complexes.

Funder

Taif University

King Abdulaziz University

Council of Scientific and Industrial Research, India

Deanship of Scientific Research, King Faisal University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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