Fe-doped carbon dot liposome enhanced radiosensitivity of tumor cells by inducing ferroptosis

Author:

Ge Guili12,Tu Hanyu3,Wang Dan2,Chen Mingjian2,Zeng Zhaoyang12,Guo Can2ORCID,Wu Xu4ORCID,Xiong Wei12ORCID

Affiliation:

1. NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, China

2. Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute and School of Basic Medical Science, Central South University, Changsha 410008, China

3. College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China

4. Department of Chemistry and Center for Fluorinated Functional Materials, University of South Dakota, Vermillion, South Dakota, 57069, USA

Abstract

Fe-CDs-PEG, a new kind of nanometer carbon dots material can catalyze H2O2 to produce ROS and effectively inhibit the proliferation of lung cancer cells through ROS, induce lung cancer cells ferroptosis, and enhance radiotherapy sensitivity.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Hunan Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

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