Biomimetic triphasic silk fibroin scaffolds seeded with tendon-derived stem cells for tendon-bone junction regeneration

Author:

Geng Yiyun12ORCID,Cui Penglei1,Hu Muli34,Zhang Bingjun15ORCID,Dai Liming1,Han Fengxuan34,Patrick Yungshu-hang6,Fu Sai-Chuen6,Li Bin34ORCID,Zhang Xiaoling15ORCID

Affiliation:

1. Department of Orthopedic Surgery, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China

2. School of Biotechnology and Food Engineering, Changshu Institute of Technology, Changshu, Jiangsu, China

3. Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, China

4. Orthopaedic Institute, Medical College, Soochow University, Suzhou, Jiangsu, China

5. National Facility for Translational Medicine, Shanghai, China

6. Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong, China

Abstract

The regeneration of tendon and bone junction (TBJ), a fibrocartilage transition zone between tendons and bones, is a challenge due to the special triphasic structure. A silk fibroin (SF)-based triphasic scaffold mimics native TBJ architecture.

Funder

National Natural Science Foundation of China

Science and Technology Commission of Shanghai Municipality

Natural Science Research of Jiangsu Higher Education Institutions of China

Shanghai Shen Kang Hospital Development Center

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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