Design, synthesis, anticancer activity and molecular docking studies of new benzimidazole derivatives bearing 1,3,4-oxadiazole moieties as potential thymidylate synthase inhibitors

Author:

Almalki Abdulraheem SA1,Nazreen Syed2ORCID,Elbehairi Serag Eldin I.34,Asad Mohammad56,Shati Ali A.3,Alfaifi Mohammad Y.3,Alhadhrami Abdulrahman1ORCID,Elhenawy Ahmed A.27ORCID,Alorabi Ali Q.2,Asiri Abdullah M.56ORCID,Alam Mohammad Mahboob2

Affiliation:

1. Department of Chemistry, Faculty of Science, Taif University, Taif, Kingdom of Saudi Arabia

2. Department of Chemistry, Faculty of Science, Al-Baha University, Al-Baha, Kingdom of Saudi Arabia

3. Department of Biology, Faculty of Science, King Khalid University, Abha 9004, Saudi Arabia

4. Cell Culture Laboratory, Egyptian Organization for Biological Products and Vaccines, VACSERA Holding Company, Giza 2311, Egypt

5. Center of Excellence for Advanced Materials Research (CEAMR), King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia

6. Chemistry Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia

7. Chemistry Department, Faculty of Science, Al-Azhar University, 11884 Nasr City, Cairo, Egypt

Abstract

Compounds 10 and 14 arrest the cell cycle at the G1 phase and induce apoptosis without any necrosis in MDA-MB-231 cells.

Funder

Taif University

King Khalid University

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

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