Human nail bed extracellular matrix facilitates bone regeneration via macrophage polarization mediated by the JAK2/STAT3 pathway-Reference-Cited by-同舟云学术

Human nail bed extracellular matrix facilitates bone regeneration via macrophage polarization mediated by the JAK2/STAT3 pathway

Published:2020 Issue:18 Volume:8 Page:4067-4079
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Yu Yaling¹²³⁴⁵^ORCID,Cui Haomin¹²³⁴,Zhang Cheng¹²³⁴,Zhang Demin⁶⁷⁸⁹⁴,Yin Jun⁶⁷⁸⁹⁴^ORCID,Wen Gen¹²³⁴,Chai Yimin¹²³⁴

Affiliation:

1. Department of Orthopedic Surgery

2. Shanghai Jiao Tong University Affiliated Sixth People's Hospital

3. Shanghai 200233

4. China

5. Institute of Microsurgery on Extremities

6. Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province

7. School of Mechanical Engineering

8. Zhejiang University

9. Hangzhou 310028

Abstract

Decellularized nail bed scaffolds (dNB) derived from amputated patients polarize macrophages towards M2 phenotype through JAK2/STAT3 signaling pathway, thus inducing osteogenic differentiation of BMSCs to facilitate calvarial defect healing.

Funder

National Natural Science Foundation of China

Shanghai Municipal Education Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2020/TB/C9TB02910A

Reference67 articles.

1. Bone regeneration strategies: Engineered scaffolds, bioactive molecules and stem cells current stage and future perspectives

2. Non-union bone fracture: a quicker fix

3. Evaluation of bone regeneration using the rat critical size calvarial defect

4. Closing the gap

5. Trapped fingers and amputated finger tips in children

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