The PI3K/AKT/mTOR interactive pathway
Author:
Affiliation:
1. Cancer Systems Biology Laboratory
2. Graduate School of Informatics
3. ODTU
4. 06800 Ankara
5. Turkey
Abstract
The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of the rapamycin (mTOR) signalling pathway is hyperactivated or altered in many cancer types and regulates a broad range of cellular processes including survival, proliferation, growth, metabolism, angiogenesis and metastasis.
Publisher
Royal Society of Chemistry (RSC)
Subject
Molecular Biology,Biotechnology
Link
http://pubs.rsc.org/en/content/articlepdf/2015/MB/C5MB00101C
Reference125 articles.
1. AKT/PKB Signaling: Navigating Downstream
2. Targeting PI3K signalling in cancer: opportunities, challenges and limitations
3. PI3K and cancer: lessons, challenges and opportunities
4. G Protein–Coupled Receptor–Mediated Activation of p110β by Gβγ Is Required for Cellular Transformation and Invasiveness
5. Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis
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