On the interactions between RNA and titrateable lipid layers: implications for RNA delivery with lipid nanoparticles-Reference-Cited by-同舟云学术

On the interactions between RNA and titrateable lipid layers: implications for RNA delivery with lipid nanoparticles

Published:2024 Issue:2 Volume:16 Page:777-794
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Gilbert Jennifer¹²^ORCID,Ermilova Inna³^ORCID,Fornasier Marco¹^ORCID,Skoda Maximilian⁴^ORCID,Fragneto Giovanna⁵⁶,Swenson Jan³^ORCID,Nylander Tommy¹²⁷⁸^ORCID

Affiliation:

1. Division of Physical Chemistry, Department of Chemistry, Naturvetarvägen 14, Lund University, 22362 Lund, Sweden

2. NanoLund, Lund University, Professorsgatan 1, 223 63 Lund, Sweden

3. Department of Physics, Chalmers University of Technology, 412 96 Gothenburg, Sweden

4. ISIS Neutron and Muon Source, Rutherford Appleton Laboratory, Harwell, Oxford OX11 0QX, UK

5. Institut Laue-Langevin, 71 avenue des Martyrs, CS 20156, 38042 Grenoble, France

6. European Spallation Source ERIC, P.O. Box 176, SE-221 00 Lund, Sweden

7. Lund Institute of Advanced Neutron and X-Ray Science, Scheelevägen 19, 223 70 Lund, Sweden

8. School of Chemical Engineering and Translational Nanobioscience Research Center, Sungkyunkwan University, Suwon, Republic of Korea

Abstract

We have investigated the interaction between a model system of DOPC/DLin-MC3-DMA, an ionisable lipid used in lipid nanoparticles for mRNA delivery, with different mRNAs and shown that the adsorption behaviour depends on the mRNA secondary structure.

Funder

Vetenskapsrådet

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2024/NR/D3NR03308B

Reference84 articles.

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2. Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

3. Lipid Nanoparticles as Delivery Systems for RNA-Based Vaccines

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5. Lipid nanoparticles for mRNA delivery

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