From sensing interactions to controlling the interactions: a novel approach to obtain biological transistors for specific and label-free immunosensing-Reference-Cited by-同舟云学术

From sensing interactions to controlling the interactions: a novel approach to obtain biological transistors for specific and label-free immunosensing

Published:2024 Issue:13 Volume:16 Page:6648-6661
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Samanta Soumadri¹^ORCID,Tiwari Vinay S.²,Sadhujan Sumesh³,Harilal Sherina³,Eisenberg-Lerner Avital⁴,Rotfogel Ziv⁴⁵,Pikhay Evgeny⁶,Shima-Edelstein Ruth⁶,Greental Doron⁶,Bashouti Muhammad Y.³⁷^ORCID,Akabayov Barak²^ORCID,Ron Izhar¹,Roizin Yakov⁶,Erez Offer⁸⁹,Shalev Gil¹⁷^ORCID

Affiliation:

1. School of Electrical Engineering, Ben-Gurion University of the Negev, Israel

2. Department of Chemistry and Data Science Research Center, Ben-Gurion University of the Negev, 8410501, Beer-Sheva, Israel

3. Department of Solar Energy and Environmental Physics, Swiss Institute for Dryland Environmental and Energy Research, J. Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev, Midreshet Ben-Gurion 8499000, Israel

4. Ophthalmology Research Laboratory, Kaplan Medical Center, Rehovot, Israel

5. Faculty of Medicine, Hadassah Medical School, The Hebrew University of Jerusalem, Jerusalem, Israel

6. Tower Semiconductor, PO Box 619, Migdal Haemek, Israel

7. The Ilse-Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, POB 653, Beer-Sheva 8410501, Israel

8. Department of obstetrics and Gynecology Soroka University Medical Center, School of Medicine, Ben Gurion University of the Negev, Beer Sheva, Israel

9. Department of Obstetrics and Gynecology, School of Medicine, Wayne State University, Detroit, MI, USA

Abstract

The MNC biosensor is employed for specific and label-free sensing of AFP from 0.5 μL drops of diluted serum with a limit-of-detection of 10.5 aM and a dynamic range extending over 6 orders of AFP concentration.

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/NR/D3NR05974J

Reference46 articles.

1. Detecting DNA and RNA and Differentiating Single-Nucleotide Variations via Field-Effect Transistors

2. Aptamer–field-effect transistors overcome Debye length limitations for small-molecule sensing

3. Detection principles of biological and chemical FET sensors

4. The interplay between pH sensitivity and label-free protein detection in immunologically modified nano-scaled field-effect transistor

5. Specific and label-free femtomolar biomarker detection with an electrostatically formed nanowire biosensor

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