An efficient strategy with a synergistic effect of hydrophilic and electrostatic interactions for simultaneous enrichment of N- and O-glycopeptides

Author:

Hu Zhonghan12,Gao Wenqing12ORCID,Liu Rong12,Yang Jiaqian12,Han Renlu12ORCID,Li Junhui12ORCID,Yu Jiancheng123,Ma Danhua4,Tang Keqi12ORCID

Affiliation:

1. Institute of Mass Spectrometry, Zhejiang Engineering Research Center of Advanced Mass spectrometry and Clinical Application, School of Material Science and Chemical Engineering, Ningbo University, Ningbo, 315211, PR China

2. Zhenhai Institute of Mass Spectrometry, Ningbo, 315211, PR China

3. Faculty of Electrical Engineering and Computer Science, Ningbo University, Ningbo, 315211, PR China

4. Department of Stomatology, Ningbo No.2 Hospital, Ningbo, 315010, PR China

Abstract

An efficient strategy was firstly proposed and successfully applied to simultaneous enrichment of N- and O-glycopeptides from complex biological samples through the synergistic effect of hydrophilic and electrostatic interactions.

Funder

Ningbo Municipal Bureau of Science and Technology

K. C. Wong Magna Fund in Ningbo University

National Natural Science Foundation of China

Key Research and Development Program of Zhejiang Province

Natural Science Foundation of Zhejiang Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

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