<sup>18</sup>F-Labeled brain-penetrant EGFR tyrosine kinase inhibitors for PET imaging of glioblastoma-Reference-Cited by-同舟云学术

¹⁸F-Labeled brain-penetrant EGFR tyrosine kinase inhibitors for PET imaging of glioblastoma

Published:2023 Issue:47 Volume:14 Page:13825-13831
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Narayanam Maruthi Kumar¹²,Tsang Jonathan E.¹,Xu Shili¹²,Nathanson David A.¹,Murphy Jennifer M.¹²^ORCID

Affiliation:

1. Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA

2. Crump Institute for Molecular Imaging, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA

Abstract

Fluorine-18 isotopologues of two EGFR tyrosine kinase inhibitors targeting glioblastoma were synthesized. In vivo PET imaging revealed rapid brain uptake and accumulation in EGFR-driven orthotopic GBM xenograft tumors, confirming target expression.

Funder

Jonsson Comprehensive Cancer Center

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC04424F

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