A natural biogenic fluorapatite as a new biomaterial for orthopedics and dentistry: antibacterial activity of lingula seashell and its use for nanostructured biomimetic coatings

Author:

Graziani Gabriela1ORCID,Ghezzi Daniele12,Nudelman Fabio3ORCID,Sassoni Enrico4,Laidlaw Fraser5,Cappelletti Martina2,Boi Marco1ORCID,Borciani Giorgia1ORCID,Milita Silvia6,Bianchi Michele7,Baldini Nicola18,Falini Giuseppe9ORCID

Affiliation:

1. Biomedical Science, Technologies, and Nanobiotecnology Lab, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

2. Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy

3. EaStCHEM School of Chemistry, The University of Edinburgh, Edinburgh, UK

4. Department of Civil, Chemical, Environmental and Materials Engineering, University of Bologna, Bologna, Italy

5. School of Physics and Astronomy, The University of Edinburgh, Edinburgh, UK

6. CNR-Institute for Microelectronic and Microsystems, Bologna, Italy

7. Department of Life Sciences, Università di Modena e Reggio Emilia, Modena, Italy

8. University of Bologna, Department of Biomedical and Neuromotor Sciences, Bologna, Italy

9. Department of Chemistry “Giacomo Ciamician”, University of Bologna, Bologna, Italy

Abstract

Lingula anatina seashell is an apatite-based shells, and naturally contains fluorine and zinc alongside an organic part (chitin). For the first time, we demonstrate that it has strong antibacterial properties, and that it can be used as nanostructured coatings for orthopaedics and dentistry.

Funder

Royal Society of Edinburgh

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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