Diverse prieurianin-type limonoids with oxygen-bridged caged skeletons from two Aphanamixis species: discovery and biomimetic conversion

Author:

Zhang Panpan12345,Xue Shang12345,Huang Wansha12345,Wang Chengcheng12345,Cui Zhirong12345,Luo Jun12345ORCID,Kong Lingyi12345ORCID

Affiliation:

1. State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product Research

2. School of Traditional Chinese Pharmacy

3. China Pharmaceutical University

4. Nanjing 210009

5. People's Republic of China

Abstract

The formation of HO-1 based oxygen-bridges and new C–C bonds via a Dieckmann reaction provided diverse ring systems, aphanamolide-type skeletons, and a solution for the structural elucidation of prieurianin limonoids with missing NMR signals.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

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