Comparative studies on in vitro antitumor activities and apoptosis-inducing effects of enantiomeric ruthenium(ii) complexes

Author:

Jiang Jianrong12234,Chen Qian12234,Huan Tianwen12234,Nie Yanhong12234,Dai Zhongming5,Li Dujuan6ORCID,Xu Xu12234ORCID,Lu Jun7,Hu Zhangli12234,Xu Hong12234ORCID

Affiliation:

1. Guangdong Technology Research Center for Marine Algal Bioengineering, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China

2. Guangdong Provincial Key Laboratory for Plant Epigenetics, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China

3. Shenzhen Engineering Laboratory for Marine Algal Biotechnology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China

4. Shenzhen Key Laboratory of Marine Bioresources and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China

5. Shenzhen University General Hospital, Shenzhen 518060, China

6. Key Laboratory of RF Circuits and Systems of Ministry of Education, Hangzhou Dianzi University, Hangzhou 310018, China

7. Auckland Bioengineering Institute, University of Auckland, Auckland 1142, New Zealand

Abstract

Both enantiomers induced the apoptosis of tumor cells by regulating mRNA expression and activating both extrinsic and intrinsic apoptosis pathways. The higher antitumor efficiency of the Δ-enantiomer should be due to its stronger interaction with DNA.

Funder

Science and Technology Program of Guangdong Province

Shenzhen Science and Technology Innovation Committee Grant

Guangxi Innovation-Driven Development Project

Southern Marine Science and Engineering Guangdong Laboratory

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

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