Activatable fluorescent probes for hydrolase enzymes based on coumarin–hemicyanine hybrid fluorophores with large Stokes shifts-Reference-Cited by-同舟云学术

Activatable fluorescent probes for hydrolase enzymes based on coumarin–hemicyanine hybrid fluorophores with large Stokes shifts

Published:2020 Issue:42 Volume:56 Page:5617-5620
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Fujioka Hiroyoshi¹²³⁴^ORCID,Uno Shin-nosuke¹²³⁴⁵,Kamiya Mako⁶²³⁴^ORCID,Kojima Ryosuke⁶²³⁴^ORCID,Johnsson Kai⁵⁷⁸⁹¹⁰,Urano Yasuteru¹²³⁴⁶

Affiliation:

1. Graduate School of Pharmaceutical Sciences

2. The University of Tokyo

3. Tokyo 113-0033

4. Japan

5. Institute of Chemical Sciences and Engineering (ISIC)

6. Graduate School of Medicine

7. École Polytechnique Fédérale de Lausanne (EPFL)

8. 1015 Lausanne

9. Switzerland

10. Department of Chemical Biology

Abstract

We show that the equilibrium of intramolecular spirocyclization of coumarin–hemicyanine hybrid fluorophores can be finely tuned by means of chemical modifications to develop activatable fluorescence probes for hydrolases with large Stokes shift.

Funder

Japan Foundation for Applied Enzymology

Astellas Foundation for Research on Metabolic Disorders

Japan Society for the Promotion of Science

Precursory Research for Embryonic Science and Technology

Japan Agency for Medical Research and Development

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CC/D0CC00559B

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