CRISPR-empowered hybridization chain reaction amplification for an attomolar electrochemical sensor

Author:

Wan Ling1,Ma Jianfeng1,Yi Jiasheng1,Dong Yan1,Niu Renjie1,Su Yan2,Li Qian3ORCID,Dan Zhu 1,Chao Jie1,Su Shao1,Fan Chunhai3ORCID,Wang Lianhui1ORCID,Wan Ying2ORCID

Affiliation:

1. State Key Laboratory of Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, 9 Wenyuan Road, Nanjing 210023, China

2. School of Mechanical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China

3. School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China

Abstract

A CRISPR-empowered electrochemical biosensor was designed for the ultrasensitive detection of the avian influenza A (H7N9) virus gene sequence.

Funder

Priority Academic Program Development of Jiangsu Higher Education Institutions

National Natural Science Foundation of China

National Key Research and Development Program of China

Natural Science Foundation of Jiangsu Province

Six Talent Peaks Project in Jiangsu Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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