Inhibitory activity of flavonoids against human sucrase-isomaltase (α-glucosidase) activity in a Caco-2/TC7 cellular model

Author:

Proença Carina1ORCID,Rufino Ana T.1ORCID,Ferreira de Oliveira José Miguel P.1ORCID,Freitas Marisa1ORCID,Fernandes Pedro A.2ORCID,Silva Artur M. S.3ORCID,Fernandes Eduarda1ORCID

Affiliation:

1. LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal

2. UCIBIO, REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal

3. QOPNA and LAQV, REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal

Abstract

Flavonoids may be effective inhibitors of SI in Caco-2/TC7 cells when using natural substrates maltose and sucrose. The chemical features that favor the SI inhibition by flavonoids are the presence of –OH groups at C-3, C-3′, C-4′, C-7 and C-8.

Funder

Fundação para a Ciência e a Tecnologia

Ministério da Ciência, Tecnologia e Ensino Superior

European Regional Development Fund

European Social Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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