The identification and use of robust transaminases from a domestic drain metagenome-Reference-Cited by-同舟云学术

The identification and use of robust transaminases from a domestic drain metagenome

Published:2019 Issue:1 Volume:21 Page:75-86
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Leipold Leona¹²³⁴,Dobrijevic Dragana⁵⁶²⁷⁴,Jeffries Jack W. E.⁵⁶²⁷⁴,Bawn Maria⁵⁶²⁷⁴,Moody Thomas S.⁸⁹⁴,Ward John M.⁵⁶²⁷⁴^ORCID,Hailes Helen C.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. University College London

3. London WC1H 0AJ

4. UK

5. The Advanced Centre for Biochemical Engineering

6. Department of Biochemical Engineering

7. London WC1E 6BT

8. Department of Biocatalysis and Isotope Chemistry

9. Craigavon

Abstract

Transaminases remain one of the most promising biocatalysts for use in chiral amine synthesis. Here, the identification, cloning and screening of novel transaminases from a drain metagenome is described, with some enzymes exhibiting outstanding properties such as 50% DMSO solvent tolerance.

Funder

Biotechnology and Biological Sciences Research Council

Almac Group

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/GC/C8GC02986E

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