Toward multifunctional anticancer therapeutics: post-synthetic carbonate functionalisation of asymmetric Au(i) bis-N-heterocyclic carbenes-Reference-Cited by-同舟云学术

Toward multifunctional anticancer therapeutics: post-synthetic carbonate functionalisation of asymmetric Au(i) bis-N-heterocyclic carbenes

Published:2020 Issue:57 Volume:56 Page:7877-7880
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Sen Sajal¹²³⁴^ORCID,Perrin Mark W.¹²³⁴,Sedgwick Adam C.¹²³⁴^ORCID,Dunsky Evie Y.¹²³⁴,Lynch Vincent M.¹²³⁴^ORCID,He Xiao-Peng⁵⁶⁷⁸⁹^ORCID,Sessler Jonathan L.¹²³⁴^ORCID,Arambula Jonathan F.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. University of Texas at Austin

3. Austin

4. USA

5. Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering

6. Feringa Nobel Prize Scientist Joint Research Center

7. School of Chemistry and Molecular Engineering

8. Frontiers Center for Materiobiology and Dynamic Chemistry

9. East China University of Science and Technology

Abstract

A post-synthetic strategy is reported that permits functionalization of Au(i)–bis NHCs via carbonate formation and synthesis of a potential multifunctional anticancer therapeutic.

Funder

National Cancer Institute

National Natural Science Foundation of China

National Institutes of Health

Science and Technology Commission of Shanghai Municipality

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CC/D0CC03339A

Reference39 articles.

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2. Dual targeting of the cancer antioxidant network with 1,4-naphthoquinone fused Gold(i) N-heterocyclic carbene complexes

3. Targeting antioxidant pathways with ferrocenylated N-heterocyclic carbene supported gold(i) complexes in A549 lung cancer cells

4. New insights in Au-NHCs complexes as anticancer agents

5. Overcoming biochemical pharmacologic mechanisms of platinum resistance with a texaphyrin–platinum conjugate

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