Hybrid natural hydrogels integrated with voriconazole-loaded microspheres for ocular antifungal applications

Author:

Wang Fuyan12345,Zhao Long45678,Song Fangying45678,Wu Jingyi45678,Zhou Qingjun45678,Xie Lixin45678ORCID

Affiliation:

1. Department of Ophthalmology

2. Clinical Medical College of Shandong University

3. China

4. State Key Laboratory Cultivation Base

5. Shandong Provincial Key Laboratory of Ophthalmology

6. Shandong Eye Institute

7. Shandong First Medical University & Shandong Academy of Medical Sciences

8. Qingdao

Abstract

Natural antifungal hydrogels that comprise a decellularized porcine cornea (DPC), gelatin and microspheres (MCs) containing voriconazole (Vor) were designed and fabricated. The natural DPC–gelatin hydrogel was used as a drug delivery vehicle for the release of Vor. This natural hydrogel-based drug delivery system holds great promise for preventing fungal keratitis infection while promoting focal corneal stromal regeneration.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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