Insulin fibril inhibition using glycopolymeric nanoassemblies

Author:

Bera Avisek1,Ghosh Pooja1,Barman Soumen2,Bhattacharya Sagnik13,Sudhamalla Babu2ORCID,Goswami Kalyan4,De Priyadarsi1ORCID

Affiliation:

1. Polymer Research Centre and Centre for Advanced Functional Materials, Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Nadia, Mohanpur – 741246, West Bengal, India

2. Department of Biological Science, Indian Institute of Science Education and Research Kolkata, Nadia, Mohanpur – 741246, West Bengal, India

3. School of Chemical Sciences, National Institute of Science Education and Research Bhubaneswar, Khurda, Jatni – 752050, Odisha, India

4. Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), Kalyani, Basantapur, NH-34 connector, Nadia, Kalyani – 741245, West Bengal, India

Abstract

Glycopolymeric nanoassemblies were designed with engineered projection of either selective or both cationic leucine/sugar residues on the outer surface of the aggregates to explore their potential role in preventing insulin fibrillation process.

Funder

Science and Engineering Research Board

Council of Scientific and Industrial Research, India

Department of Science and Technology, Ministry of Science and Technology, India

Department of Biotechnology, Ministry of Science and Technology, India

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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