A novel indomethacin/methotrexate/MMP-9 siRNA in situ hydrogel with dual effects of anti-inflammatory activity and reversal of cartilage disruption for the synergistic treatment of rheumatoid arthritis-Reference-Cited by-全球学者库

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A novel indomethacin/methotrexate/MMP-9 siRNA in situ hydrogel with dual effects of anti-inflammatory activity and reversal of cartilage disruption for the synergistic treatment of rheumatoid arthritis

Published:2020 Issue:15 Volume:12 Page:8546-8562
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Yin Na¹²³⁴,Tan Xinyi¹²³⁴,Liu Hongbing¹²³⁴,He Fengming⁵⁶⁷⁴,Ding Ning¹²³⁴,Gou Jingxin¹²³⁴,Yin Tian⁸²³⁴,He Haibing¹²³⁴,Zhang Yu¹²³⁴^ORCID,Tang Xing¹²³⁴^ORCID

Affiliation:

1. Department of Pharmaceutics

2. Shenyang Pharmaceutical University

3. Shenyang

4. China

5. School of Pharmaceutical Sciences

6. Xiamen University

7. Xiamen

8. School of Functional Food and Wine

Abstract

The D/siRNA-NGel was constructed to alleviate pain and swelling, delay the progression of RA, and reverse cartilage and bone disruption.

Funder

China Postdoctoral Science Foundation

Doctoral Start-up Foundation of Liaoning Province

Natural Science Foundation of Liaoning Province

Shenyang Pharmaceutical University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2020/NR/D0NR00454E

Reference60 articles.

1. Evolving concepts of rheumatoid arthritis

2. Pathogenetic insights from the treatment of rheumatoid arthritis

3. Pro-and Anti-inflammatory Cytokines in Rheumatoid Arthritis

4. Nanotherapeutics relieve rheumatoid arthritis

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1. Macrophage-hitchhiking interleukin-10 plasmid DNA delivery system modulates rheumatoid arthritis microenvironment via the re-polarization of macrophages;Nano Today;2024-02

2. Development of Biomedical Hydrogels for Rheumatoid Arthritis Treatment;Asian Journal of Pharmaceutical Sciences;2024-02

3. Multifunctional nanoparticle-mediated combining therapy for human diseases;Signal Transduction and Targeted Therapy;2024-01-01

4. Overcoming delivery barriers for RNA therapeutics in the treatment of rheumatoid arthritis;European Journal of Pharmaceutics and Biopharmaceutics;2023-11

5. Application of Cartilage Extracellular Matrix to Enhance Therapeutic Efficacy of Methotrexate;Tissue Engineering and Regenerative Medicine;2023-10-14

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