Exploring the synthetic potential of dihydroxyacetone-aldolases from acidophilic organisms

Author:

Paulat Léo1,Gastaldi Cédric1,Nauton Lionel1,Theveniot Mariline1,Joly Muriel1,Petit Jean-Louis2,de Berardinis Véronique2,Hélaine Virgil1ORCID,Guérard-Hélaine Christine1ORCID

Affiliation:

1. Université Clermont Auvergne, Clermont Auvergne INP, CNRS, Institut de Chimie de Clermont-Ferrand, 63000 Clermont-Ferrand, France

2. Génomique Métabolique, Genoscope, Institut François Jacob, CEA, CNRS, Univ-Evry, Université Paris-Saclay, Evry-Courcouronnes, 91057 Evry, France

Abstract

Two novel dihydroxyacetone-aldolases showcase unique characteristics, distinguishing them from the E. coli counterpart. They enable efficient synthesis of a diverse array of known monosaccharides along with novel compounds previously inaccessible.

Funder

Agence Nationale de la Recherche

Publisher

Royal Society of Chemistry (RSC)

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