Optimization of magnetic nanoparticles for engineering erythrocytes as theranostic agents

Author:

Slavu Laura Maria1ORCID,Antonelli Antonella2ORCID,Scarpa Emanuele Salvatore2,Abdalla Pasant2,Wilhelm Claire3,Silvestri Niccolò4,Pellegrino Teresa4ORCID,Scheffler Konrad5ORCID,Magnani Mauro2,Rinaldi Rosaria167,Di Corato Riccardo78ORCID

Affiliation:

1. Mathematics and Physics “E. De Giorgi” Department, University of Salento, Via Monteroni, Lecce 73100, Italy

2. Dipartimento di Scienze Biomolecolari, Università degli Studi di Urbino Carlo Bo, Via Saffi 2, Urbino 61029, Italy

3. Laboratoire Physico Chimie Curie, UMR 168, CNRS, Institut Curie, PSL University, Sorbonne Université, 75005 Paris, France

4. Italian Institute of Technology, via Morego 30, 16131 Genoa, Italy

5. Section for Biomedical Imaging, University Medical Center Hamburg-Eppendorf, 22529 Hamburg, Germany

6. Scuola Superiore ISUFI, University of Salento, Via Monteroni, University Campus, Lecce 73100, Italy

7. Institute for Microelectronics and Microsystems (IMM), CNR, Via Monteroni, Lecce 73100, Italy

8. Center for Biomolecular Nanotechnologies, Istituto Italiano di Tecnologia, Arnesano 73010, Italy

Abstract

The synthesis of magnetic nanoparticles (based on iron oxide or Zn/Mn ferrite) has been optimized, through the evaluation of different parameters, for encapsulation into human and murine red blood cells.

Funder

European Regional Development Fund

European Social Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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